So, you've never played guitar before, and you have no idea what you're looking for, but you see one that looks like it's come straight from Beelzebub's Den, and seems great!
Supposing you don't yet have a teacher, you might consider contacting one locally first, but if you're still set on picking out a guitar yourself, here are some tips.
To me, first and foremost is the quality of the tuners for a beginner. The tuning machines should be able to maintain a pitch with no problem. If you play an open string and it sounds like a dying cat falling down a cliff...
Next, you want to consider playability: How easy is it to play this guitar? The guitar should first be easy to hold. You want to feel comfortable when you hold the guitar, something that's difficult to hold will only be more frustrating. You have enough to get frustrated over as you begin playing; holding the guitar should be your last concern. Now, maybe you have no idea how to play yet, but you kind of understand the general premise of how the guitar is played from pictures, videos, or just your best friend jammin out on Rock Band. You should try to play something on the guitar; if it seems exceedingly difficult or uncomfortable, find one that feels better.
The next consideration is not as important because it is typically relatively adjustable, but be aware of the action of the guitar. Action is a part of playability, and is the height of the strings off of the fingerboard.
You should also consider intonation. This is not something you may be able to judge, and is one of the reasons I recommend a teacher. However, if you want to check this, one quick judge is this: (USING A TUNER) if you play the first string open, it should be an "E." If you play the same string while pressing the string to the twelfth fret, it should sound an "E" but an octave higher. (While looking at the tuner, be sure it does not say Eb or E#, there is usually an extra little light to suggest the difference)
Finally, a general rule of thumb is: IF IT LOOKS LIKE A TOY, WELL.....
Remember, buy something that works well for you and sounds good. You don't have to be a millionaire to get a great starter guitar, but you want to be conscious of quality, and you want something that will hold up for a while. Make sure you do LOTS of shopping and playing first! Happy Shopping!